RESTORE

Study information

Persistent insomnia affects approximately 10% of the adult population and is a risk factor for several mental and physical health problems, particularly depression and cardiometabolic disease. The primary aim of this trial is to establish in a real world setting, whether short-term treatment of Chloral Hydrate is effective in patients with severe insomnia which is interfering with normal daily life and where other therapies (behavioural and pharmacologic) have failed. Secondary objectives will assess safety, tolerability, identification of baseline characteristics, changes in quality of life and self-reported sleep, within a real world setting.

Status: Recruitment now closed.

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Recruitment area

RESTORE is a decentralised clinical trial, so patients are screened completely online remotely by the study centre staff and do not need to physically travel to any centres or clinics. As such, this trial is recruiting across the country covering most (but not all) areas.

Specifically, recruitment will target:

• Practices within a 34 mile radius of central Birmingham and central Manchester
• Practices within a 60 mile radius of central London
• Practices within a 70 mile radius of central Newcastle
• Practices within a 100 mile radius of Launceston